Photocleavable Surfactant-Enabled Extracellular Matrix Proteomics
نویسندگان
چکیده
منابع مشابه
Using extracellular matrix proteomics to understand left ventricular remodeling.
Survival following myocardial infarction has improved substantially over the last 40 years; however, the incidence of subsequent congestive heart failure has increased dramatically as a consequence. Discovering plasma markers that signify adverse cardiac remodeling may allow high-risk patients to be recognized earlier and may provide an improved way to assess treatment efficacy. Alterations in ...
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Prolonged myocardial ischemia leads to myocyte necrosis, which initiates a localized inflammatory response that catabolizes the cellular debris and initiates deposition of extracellular matrix (ECM) proteins.1 In addition to providing a vital structural framework for the three-dimensional organization of cells, the ECM determines the physical properties of biological tissues and acts as a dynam...
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BACKGROUND The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS We performed a proteomics comparison of the vascular extracellular matrix an...
متن کاملProteomics Analysis of the Zebrafish Skeletal Extracellular Matrix
The extracellular matrix of the immature and mature skeleton is key to the development and function of the skeletal system. Notwithstanding its importance, it has been technically challenging to obtain a comprehensive picture of the changes in skeletal composition throughout the development of bone and cartilage. In this study, we analyzed the extracellular protein composition of the zebrafish ...
متن کاملExtracellular Matrix
The tissues of a multicellular organism contain two main components, the cells themselves, onwhichmost biological research has traditionally focused, and the material that lies between the cells. This material is called the extracellular matrix, usually abbreviated to ‘ECM’. The ratio of tissue volume occupied by ECM to that occupied by cells varies from less than 1:10 (e.g. in muscles) to more...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2020
ISSN: 0003-2700,1520-6882
DOI: 10.1021/acs.analchem.0c03104